A stereoselective synthesis of the C(1)-C(16) fragment of the bryostatins |
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Authors: | Matthew Ball |
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Affiliation: | Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK |
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Abstract: | A synthesis of the C(1)-C(16) fragment of the brysostatins has been developed. Key steps are the stereoselective copper(I) catalysed addition of allylmagnesium bromide to an alkynyl ester, a condensation of a βγ-unsaturated aldehyde with a ketophosphonate, and the formation of the B-ring under mild conditions by stereoselective intramolecular conjugate addition. |
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