Convenient synthesis of porphine from β-tetra(tert-butyl)porphyrin |
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| Authors: | Saburo Neya Jingshun Quan Masayuki Hata |
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| Institution: | a Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
b Department of Physical Chemistry, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8414, Japan |
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| Abstract: | β-Tetra(tert-butyl)porphyrin was prepared from 2-dimethylaminomethyl-4-tert-butylpyrrole and converted into porphine, the mother compound of porphyrins, in 64% yield. The dealkylation smoothly proceeded in aqueous sulfuric acid over 15 min at 190 °C under nitrogen. |
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| Keywords: | De-tert-butylation Hydrated sulfuric acid β-Tetra(tert-butyl)porphyrin Porphine |
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