An efficient synthesis of (−)-3-deazaaristeromycin |
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Authors: | Minmin Yang |
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Institution: | Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312, USA |
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Abstract: | The coupling reaction of 4-chloro-1H-imidazo4,5-c]pyridine (6-chloro-3-deazapurine) and (3aS,4S,6R,6aR)-tetrahydro-2,2-dimethyl-6-vinyl-3aH-cyclopenta-d]1,3]dioxo-4-ol under Mitsunobu reaction conditions provides, after three subsequent straightforward reactions, ready access to the highly biologically active (−)-3-deazaaristeromycin. The versatility of this procedure opens access to a diverse pool of 3-deazapurine carbocyclic nucleosides. |
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Keywords: | Carbocyclic nucleosides Aristeromycin 3-Deazapurine Mitsunobu reaction |
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