Polymorphism of (+)N-tosyl-L-glutamic acid |
| |
Authors: | H. Hajmowicz L. Synoradzki K. Bujnowski J. Zachara |
| |
Affiliation: | (1) Faculty of Chemistry, Laboratory of Technological Processes, Warsaw University of Technology, Noakowskiago 3, 00-664 Warsaw, Poland |
| |
Abstract: | It has been shown that polymorphism is the reason for the occurrence of (+)N-tosyl-L-glutamic acid 1 with various melting points. 1 occurs in two crystalline forms: and . Form -1 (prisms) having a melting point of 145–147°C is chemically pure and stable. Form -1, however, is unstable and is formed as a result of the stabilizing effect of an organic solvent not introduced into the structure of the crystal. At about 125°C the forms is transformed to the form. The melting point of the form depends on the amount and type of solvent contained in the crystal, which, during measurement cannot leave the system. |
| |
Keywords: | crystallization melting point N-tosyl-L-glutamic acid polymorphism thermogravimetric analysis X-ray powder diffraction |
本文献已被 SpringerLink 等数据库收录! |
|