Incorporation of ionic liquid into porous polymer monoliths to enhance the separation of small molecules in reversed‐phase high‐performance liquid chromatography |
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| Authors: | Jiafei Wang Ligai Bai Zhen Wei Junxiao Qin Yamin Ma Haiyan Liu |
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| Institution: | Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, China |
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| Abstract: | An ionic liquid was incorporated into the porous polymer monoliths to afford stationary phases with enhanced chromatographic performance for small molecules in reversed‐phase high‐performance liquid chromatography. The effect of the ionic liquid in the polymerization mixture on the performance of the monoliths was studied in detail. While monoliths without ionic liquid exhibited poor resolution and low efficiency, the addition of ionic liquid to the polymerization mixture provides highly increased resolution and high efficiency. The chromatographic performances of the monoliths were demonstrated by the separations of various small molecules including aromatic hydrocarbons, isomers, and homologues using a binary polar mobile phase. The present column efficiency reached 27 000 plates/m, which showed that the ionic liquid monoliths are alternative stationary phases in the separation of small molecules by high‐performance liquid chromatography |
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| Keywords: | Ionic liquids Porous polymer monoliths Reversed phase High‐performance liquid chromatography Small molecule separations |
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