| A New Cytotoxic Sterol Produced by an Endophytic Fungus from Castaniopsisfissa at the South China Sea Coast |
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| 引用本文： | HouJinLI YongChengLIN L.L.P.VRIJMOED E.B.G.JONES. A New Cytotoxic Sterol Produced by an Endophytic Fungus from Castaniopsisfissa at the South China Sea Coast[J]. 中国化学快报, 2004, 15(4): 419-422 |
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| 作者姓名： | HouJinLI YongChengLIN L.L.P.VRIJMOED E.B.G.JONES |
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| 作者单位： | [1]DepartmentofAppliedChemistry,ZhongshanUniversity,Guangzhou510275 [2]DepartmentofBiologyandChemistry,CityUniversityofHongKong,HongKong |
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| 摘 要： | A new sterol,ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A) together withthree known sterols:3β,5α,6β-trihydroxyergosta-7,22-diene(B),3β-hydroxy-5α,8α- epidioxyergosta-6,22-diene (C) and ergosterol (D) were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa (chestnut tree).Compound A exhibited potent selective cytotoxicity against Bel-7402,NCI4460 and L-02 cell lines with IC50 values 8.445,5.03,13.621μg/mL,respectively.
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| 关 键 词： | 内寄生菌 固酮 细胞毒素 麦角-8（9） 22-二烯-3 5 6 7-四（3β 5α 6β 7α 22E） |
A New Cytotoxic Sterol Produced by an Endophytic Fungus from Castaniopsis fissa at the South China Sea Coast |
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| Hou Jin LI,Yong Cheng LIN,L. L. P. VRIJMOED,E. B. G. JONES. A New Cytotoxic Sterol Produced by an Endophytic Fungus from Castaniopsis fissa at the South China Sea Coast[J]. Chinese Chemical Letters, 2004, 15(4): 419-422 |
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| Authors: | Hou Jin LI Yong Cheng LIN L. L. P. VRIJMOED E. B. G. JONES |
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| Affiliation: | Hou Jin LI,Yong Cheng LIN,L. L. P. VRIJMOED,E. B. G. JONESDepartment of Applied Chemistry,Zhongshan University,Guangzhou 510275 Department of Biology and Chemistry,City University of Hong Kong,Hong Kong |
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