| 化学发光免疫分析试剂吖啶酯的合成新路线 |
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| 引用本文： | 庄惠生,王琼娥,陈国南,张帆. 化学发光免疫分析试剂吖啶酯的合成新路线[J]. 高等学校化学学报, 1998, 19(12): 1933-1936 |
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| 作者姓名： | 庄惠生 王琼娥 陈国南 张帆 |
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| 作者单位： | 福州大学化学系, 福州, 350002 |
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| 基金项目： | 国家自然科学基金,国家教育部材料和生命过程分析科学实验室 |
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| 摘 要： | 设计了一种化学发光免疫分析试剂吖啶酯的合成新路线,以二苯胺为原料合成吖啶-9-羧酸,经酰氯化后与3-(4-羟基苯基)-丙酸-N-羟基琥珀酰亚胺酯反应得4-(2-琥珀酰亚胺基氧羰基乙基)苯基-9-吖啶羧酸酯,最后与氟磺酸甲酯反应即得4-(2-琥珀酰亚胺基氧羰基)苯基-10-甲基吖啶-9-羧酸酯氟磺酸盐(俗称吖啶酯).
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| 关 键 词： | 4-(2-琥珀酰亚胺基氧羰基)苯基-10-甲基吖啶-9-羧酸酯氟磺酸盐 化学发光免疫分析 合成 二苯胺 |
| 收稿时间： | 1997-12-10 |
A Novel Synthesis of Acridinium Ester as a Chemiluminescent Immunoassay Reagent |
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| ZHUANG Hui-Sheng,WANG Qiong-E,CHEN Guo-Nan,ZHANG Fan. A Novel Synthesis of Acridinium Ester as a Chemiluminescent Immunoassay Reagent[J]. Chemical Research In Chinese Universities, 1998, 19(12): 1933-1936 |
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| Authors: | ZHUANG Hui-Sheng WANG Qiong-E CHEN Guo-Nan ZHANG Fan |
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| Affiliation: | Department of Chemistry, Fuzhou University, Fuzhou, 350002 |
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| Abstract: | A novel synthesis of acridinium ester as a chemiluminescent immunoassay reagent was designed in this paper. This novel synthesis involved the production of acridine 9 carboxylic acid from diphenylamine, the acridine 9 carboxylic acid was converted to acridine 9 carbonylchloride, and reacted with 4 (2 N succinimdyloxycarbonylethyl) phenol, to produce 4 (2 succinimdyloxycarbonylethyl) phenyl 9 acridine carboxylate, this is followed by conversion to 4 (2 succinimdyloxycarbonylethyl) phenyl 10 methylacridinum 9 carboxylate fluorosulfonate(so called acridinium ester). |
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| Keywords: | succinimdyloxycarbonylethyl) phenyl 10 methylacridinum 9 carboxylate fluo rosulfonate Chemiluminescent immunoassay Synthesis Diphenylamine |
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