Tandem intramolecular silylformylation-crotylsilylation: highly efficient synthesis of polyketide fragments |
| |
Authors: | Zacuto Michael J O'Malley Steven J Leighton James L |
| |
Affiliation: | Department of Chemistry, Columbia University, New York, New York 10027, USA. |
| |
Abstract: | Polyketide fragments may be rapidly and efficiently assembled in the tandem intramolecular silylformylation-crotylsilylation of alkenes and alkynes. The reactions establish up to three new stereocenters with good-to-excellent diastereoselectivity, and the use of the reaction in an iterative sense is demonstrated. In addition, a new dihydrosilane alcoholysis reaction has been developed, leading to a highly efficient sequence. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|