| 含核酸碱基的双亲聚合物纳米球的制备及性能 |
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| 引用本文： | 张笑,何振峰,李广全,张瑀健,陈云霞,李国文.含核酸碱基的双亲聚合物纳米球的制备及性能[J].高等学校化学学报,2009,30(1):208-211. |
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| 作者姓名： | 张笑 何振峰 李广全 张瑀健 陈云霞 李国文 |
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| 作者单位： | 吉林大学超分子结构与材料国家重点实验室,长春,130012 |
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| 摘 要： | 设计并合成了含有核酸碱基腺嘌呤的双亲聚合物, 聚聚乙二醇600-5-氧-(6-腺嘌呤代己烷基)-异酞酸酯](PPEAHI), 研究了其在水溶液中的自组织行为, SEM观测了该聚合物在水溶液中的聚集形态, 表明PPEAHI在水溶液中自组织成纳米球. 将纳米球水溶液冻干后, 用FTIR研究了PPEAHI聚合物上的腺嘌呤与底物胸腺嘧啶间的相互作用, 结果表明受体与底物的互补基团间形成了氢键, 发生了分子识别, 并用变温红外光谱进一步证实了氢键的形成.
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| 关 键 词： | 双亲聚合物 纳米球 核酸碱基 分子识别 |
| 收稿时间： | 2008-04-29 |
Preparation and Properties of Ampliphilic Polymer Nanospheres Containing Nucleobases |
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| ZHANG Xiao,HE Zhen-Feng,LI Guang-Quan,ZHANG Yu-Jian,CHEN Yun-Xia,LI Guo-Wen.Preparation and Properties of Ampliphilic Polymer Nanospheres Containing Nucleobases[J].Chemical Research In Chinese Universities,2009,30(1):208-211. |
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| Authors: | ZHANG Xiao HE Zhen-Feng LI Guang-Quan ZHANG Yu-Jian CHEN Yun-Xia LI Guo-Wen |
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| Institution: | State Key Laboratory of Supramolecular Structure and Materials;Jilin University;Changchun 130012;China |
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| Abstract: | An amphiphilic polymer containing adenine,poly(polyoxyethylene-600)-oxy-5-6-(1-adenine) hexyl] isophthaloyl(PPEAHI),was synthesized. The self-organized behavior of the amphiphilic polymer in dilute aqueous solution was studied. The morphology of the aggregates was observed via SEM. The result indicates that the amphiphilic PPEAHI polymer is self-organized into nanospheres in dilute aqueous solution. The molecular recognition between adenine in PPEAHI polymer and thymine substrate was studied via FTIR,whic... |
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| Keywords: | Amphiphilic polymer Nanosphere Nucleobase Molecular recognition |
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