Versatile, diastereoselective additions of silyl ketene acetals, allyl tributylstannane, and Me(3)SiCN to N-acyl pyrazolines: asymmetric synthesis of densely functionalized pyrazolidines |
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Authors: | Guerra Mish Carreira |
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Institution: | Laboratorium fur Organische Chemie, ETH-Zentrum, Universitatrasse 16, CH-8092 Zurich, Switzerland. |
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Abstract: | We report the diastereoselective addition of a wide range of nucleophiles to chiral pyrazolines to provide facile access to a range of useful densely functionalized building blocks for asymmetric synthesis. Coupled with the asymmetric cycloaddition reaction of Me(3)SiCHN(2) to chiral acrylates, access to these chiral heterocycles is considerably expanded. |
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