Scope and limitations of chiral B- |
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| Authors: | Ishihara Kondo Yamamoto |
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| Institution: | Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan, CREST, Japan Science and Technology Corporation (JST), and Research Center for Advanced Waste and Emission Management (ResCWE), Furo-cho, Chikus. |
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| Abstract: | A new chiral oxazaborolidine catalyst was prepared in situ from 3, 5-bis(trifluoromethyl)phenylboron dichloride and N-(p-toluenesulfonyl)-(S)-tryptophan. This catalyst is much more active than Corey's original catalyst for the Mukaiyama aldol reaction of aldehydes with silyl enol ethers. The observed syn selectivities and re-face attack of silyl enol ethers on carbonyl carbon of aldehydes imply that the extended-transition state model is applicable. |
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