Synthesis of Pyrimidinone and 5‐unsubstituted 4, 6‐diarylpyrimidine‐2(1H)‐ones by Using Nano Magnetic Catalyst under Solvent Free Condition |
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Authors: | Ali Amoozadeh Saeede Azhari Eskandar Kolvari Somayeh Otokesh |
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Institution: | 1. Department of Organic Chemistry, Faculty of Chemistry, Semnan University, Semnan, Iran, Tel: +982333366177;2. , Fax: +98 (23) 33354082 |
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Abstract: | Nano magnetic‐supported sulfonic acid is found to be a powerful and reusable heterogeneous catalyst for the efficient synthesis of pyrimidinones. In this study we use various ketones such as acetophenone and cyclopentanone instead of β‐keto ester in one‐pot synthesis of pyrimidinone at biginelli like reaction. Our objective is to improve conditions for the synthesis of multicomponent reactions using nano magnetic catalyst under solvent free condition. A number of excellent and significant results have been developed that lead our perspective understanding the effect of the magnetic nanoparticles when they are used as catalysts. |
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Keywords: | Nano magnetic‐supported sulfonic acid Heterogeneous catalyst Pyrimidinones Acetophenone Cyclopentanone Solvent free condition |
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