| Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer |
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| 作者姓名： | Yu Li Hui Bin Zhang Wen Long Huang Xia Zhen Yun Man Li |
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| 作者单位： | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | Tetrahydroisoquinoline derivatives were synthesized and their multidrug resistance reversal activities were evaluated in vitro. The results showed that some of the synthetic compounds had higher multidrug resistance （MDR） reversal activities than verapamil.
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| 关 键 词： | 四氢化异喹啉 派生物 合成方法 类酞 |
| 收稿时间： | 2007-10-22 |
Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer |
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| Yu Li Hui Bin Zhang Wen Long Huang Xia Zhen Yun Man Li.Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer[J].Chinese Chemical Letters,2008,19(2):169-171. |
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| Authors: | Yu Li Hui Bin Zhang Wen Long Huang Xia Zhen Yun Man Li |
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| Institution: | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Tetrahydroisoquinoline derivatives were synthesized and their multidrug resistance reversal activities were evaluated in vitro.The results showed that some of the synthetic compounds had higher multidrug resistance (MDR)reversal activities than verapamil. |
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| Keywords: | Tetrahydroisoquinoline derivatives Synthesis Multidrug resistance (MDR) Peptoids |
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