Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite |
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Authors: | Delgado-Pinar Estefanía Albelda M Teresa Frías Juan C Barreiro Olga Tejera Emilio Kubíček Vojtěch Jiménez-Borreguero Luis J Sánchez-Madrid Francisco Tóth Eva Alarcón Javier García-España Enrique |
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Institution: | Instituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, Edificio de Institutos de Paterna, C/Catedrático José Beltrán 2, Apartado de Correos 22085, 46071, Valencia, Spain. |
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Abstract: | The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles. |
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