Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization |
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| Authors: | Wang Huifeng Li Yaming Jiang Linlin Zhang Rong Jin Kun Zhao Defeng Duan Chunying |
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| Institution: | State Key Laboratory of Fine Chemicals, College of Chemical Engineering, Dalian University of Technology, Dalian, 116012, China. |
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| Abstract: | A wide range of free N-H 2-arylindoles were synthesised via the copper(II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application. |
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