| TEBA催化合成非诺贝特酸 |
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| 引用本文： | 乔德阳,李敢. TEBA催化合成非诺贝特酸[J]. 合成化学, 2009, 17(6) |
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| 作者姓名： | 乔德阳 李敢 |
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| 作者单位： | 徐州工业职业技术学院,江苏,徐州,221140;江苏恩华药业股份有限公司,江苏,徐州,221007 |
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| 摘 要： | 在50%氢氧化钾溶液中,4-羟基-4'-氯二苯甲酮(1),氯仿和丙酮在相转移催化剂TEBA的催化下发生缩合反应合成了非诺贝特酸.最佳反应条件为:1 30 g,丙酮120 g,TEBA 2.5 g,氯仿40 g,于30 ℃滴加氯仿,产率89.7%.
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| 关 键 词： | 非诺贝特酸 相转移催化 药物合成 |
Catalytic Synthesis of Fenofibrate Acid by TEBA |
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| QIAO De-yang,LI Gan. Catalytic Synthesis of Fenofibrate Acid by TEBA[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(6) |
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| Authors: | QIAO De-yang LI Gan |
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| Abstract: | Fenofibrate acid was synthesized by the condensation reaction of 4-hydroxy-4'-chlorobenzophenone(1)with chloroform and acetone in 50% KOH solution using TEBA as the phase-transfer catalyst. The optimum reaction conditions were as follows: 1 was 30 g; TEBA was 2.5 g; chloroform (adding dropwise at 30 ℃) was 40 g; acetone was 120 g. The yield was 89.7% under the optimum reaction conditions. |
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| Keywords: | Fenofibrate acid phase-transfer catalysis drug synthesis |
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