Star‐Shaped Polymer Consisting of a Porphyrin Core and Poly(L‐lysine) Dendron Arms: Synthesis,Drug Delivery,and In Vitro Chemo/Photodynamic Therapy |
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Authors: | Dong Ma Zong‐Hua Liu Qian‐Qian Zheng Xiao‐Yan Zhou Yi Zhang Yun‐Feng Shi Jian‐Tao Lin Wei Xue |
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Abstract: | A novel star‐shaped polymer, porphyrin‐poly(L‐lysine) dendrons (PP‐PLLD), is synthesized by the click reaction between azido‐modified porphyrin and propargyl focal point poly(L‐lysine) dendrons. Its chemical structure is characterized by 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP‐PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μg mg−1. By in vitro toxicity assay, PP‐PLLD has no dark cytotoxicity but has significant phototoxicity. Moreover, DOX‐loaded PP‐PLLD shows a higher cytotoxicity under the light condition than PP‐PLLD or DOX alone, suggesting PP‐PLLD has a potential application in combined photodynamic therapy and chemotherapy. |
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Keywords: | combined therapy dendrons poly(L‐lysine) porphyrin star polymers |
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