Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings |
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Authors: | Vladimir Egorov Alexey Tatarinov Noune Sarvazyan Randee Wood Leonid Magidenko Shreyasee Amin Sundeep Khosla Richard J. Ruh Jennifer M. Ruh Armen Sarvazyan |
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Affiliation: | 1. Artann Laboratories, Trenton, NJ 08618, USA;2. Health Smart Medical Center, Philadelphia, PA 19115, USA;3. Mayo Clinic, Rochester, MN 55905, USA;4. Catholic Health, Sisters of Charity Hospital, Buffalo, NY 14214, USA |
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Abstract: | The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score <−2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS’s capability to detect osteoporosis in postmenopausal women. |
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Keywords: | AUC, area under ROC curve BMD, bone mineral density BMI, body mass index BQI, Bone Quality Index BUSS, bone ultrasonic scaner DXA, dual-energy X-ray absorptiometry ROC, receiver operating characteristic |
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