Synthesis, characterization, DNA binding and cleavage properties and anticancer studies of ruthenium(III) Schiff base complexes |
| |
| Authors: | Gunasekaran Raja Ray J Butcher Chinnasamy Jayabalakrishnan |
| |
| Institution: | (1) Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641 020, Tamil Nadu, India;(2) Department of Chemistry, Howard University, Washington, DC 20059, USA; |
| |
| Abstract: | A Schiff base (HL) has been synthesized and characterized by physico-chemical, spectroscopic and X-ray crystallography studies.
Three of its Ru(III) complexes were synthesized and characterized by analytical and spectroscopic studies. The DNA binding
properties of HL and its Ru(III) complexes have been investigated by electronic absorption spectroscopy. Also, HL and its
Ru(III) complex RuCl2(AsPh3)L] were tested for DNA cleavage properties. The results showed that the complex cleaves DNA more rapidly than the free ligand.
Further, an in vitro study of the cytotoxicity of HL and the complex RuCl2(AsPh3)L] was carried out. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
