聚硅氧烷皮肤组织黏接材料的设计合成与性能表征

设计开发了以聚硅氧烷材料为基础的皮肤组织黏接剂, 其主要由硅氧烷预聚体、 含氢硅油交联剂和卡斯特催化剂等多组分构成. 在卡斯特催化剂作用下, 预聚体和交联剂室温下在皮肤表面原位快速固化, 其中聚硅氧烷预聚体的苯甲醛侧基与皮肤组织中广泛存在的胺基通过醛胺缩合反应实现共价黏接. 本文系统研究了聚硅氧烷预聚体的聚合度、 侧基含量及交联剂的用量等参数对该黏接剂性能的影响, 得到了最大剪切黏接强度为77.6 KPa、 室温条件下100 s内即可形成稳定黏接的组织黏接材料. 该材料还具有良好的力学相容性、 生物安全性和结构稳定性, 可满足皮肤黏接剂的基本要求, 具有较好的应用前景.

Preparation and Properties Characterization of Polysiloxane Skin Tissue Adhesive

Skin is inevitably injured as the outermost organ of human body in daily life. Suture is the main methods to deal with the open skin wounds. However， even if suture can effectively close the open wounds， it may cause some defects such as secondary damage and scars. It is ideal to develop the tissue adhesive with good performance to replace the suture. Based on the analysis of properties requirements of skin tissue adhesive， a polysiloxane skin tissue adhesive was designed and synthesized which is consisted of prepolymer poly（dimethyl siloxane）_n-co-poly（propoxybenzaldehyde methyl siloxane）_m（PDMS_n-PBAMS_m）， crosslinker poly（hydromethyl siloxame）PHMS and Karstedt’s catalyst. Among them， the side groups of prepolymer with functional modification can covalently interact with skin， prepolymer and PHMS can occur rapid in situ curing reaction to achieve adhesion on skin. The results indicate that polysiloxane tissue adhesive has compatible mechanical properties with skin through adjusting the degree of polymerization（DP） of prepolymer， modified proportion of functional group and content of PHMS. The adhesion tests indicate that the polysiloxane has good adhesive property for hogskin and the maximum shear adhesive strength is 77.6 kPa. In addition， prepolymer and PHMS complete in situ curing process in about 100 s at room temperature. Polysiloxane adhesvie can meet the property requirements as a good skin tissue adhesive and has a good application prospect in regenerative medicine.