核酸适体靶向的膜蛋白识别与功能调控研究进展

膜蛋白在细胞生命活动中发挥着重要作用, 研究并调控细胞膜蛋白的结构和功能有助于阐明生命活动的基本规律, 为新型药物研发和高效疾病诊治提供研究基础. 核酸适体是一类特殊的寡核苷酸序列, 因具有特异性识别靶标的能力而被广泛用于生物传感领域. 将核酸适体与DNA纳米技术相结合, 利用DNA分子可程序化设计、 可功能化修饰等优势, 发展核酸适体靶向的膜蛋白识别与功能调控方法可为研究膜蛋白相互作用提供有力工具. 本文介绍了基于核酸适体靶向识别的DNA纳米技术在膜蛋白识别及细胞功能调控中的研究进展, 并对核酸适体靶向的膜蛋白识别及功能调控领域面临的挑战进行了分析， 对其应用前景进行了展望.

Progress in Aptamer-targeted Membrane Protein Recognition and Functional Regulation

Membrane protein plays an important role in various biological process. Modulation the structural and functional property of membrane protein would help to clarify the fundamental molecular mechanisms and provide basis for drug discovery and efficient therapeutic strategy. Aptamer is a special kind of oligonucleotide which can bind to its target efficiently. Due to its unique properties， aptamer is widely used in biosensing application. As a biological material， DNA molecule possesses the advantages of programmable design and facile functionalization. Thus， the combination of aptamer with DNA nanotechnology would provide a powerful tool for studying the interactions between membrane proteins. This review summarizes the recent research progress on aptamer-targeted membrane protein recognition and functional regulation utilizing DNA nanotechnology. The promising prospects and challenges in the future application of aptamer-targeted membrane protein recognition and functional regulation are also highlighted.