Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis |
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| Authors: | Haynes Stuart W Sydor Paulina K Stanley Anna E Song Lijiang Challis Gregory L |
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| Affiliation: | Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL. |
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| Abstract: | The function of RedH from Streptomyces coelicolor as an enzyme that catalyses the condensation of 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrole to form the natural product undecylprodiginine has been experimentally proven, and the substrate specificity of RedH has been probed in vivo by examining its ability to condense chemically-synthesised MBC analogues with 2-undecylpyrrole to afford undecylprodiginine analogues. |
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