Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase |
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| Authors: | Gray Christopher A de Lira Simone P Silva Marcio Pimenta Eli F Thiemann Otavio H Oliva Glaucius Hajdu Eduardo Andersen Raymond J Berlinck Roberto G S |
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| Institution: | Department of Chemistry, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 Canada. |
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| Abstract: | Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 microM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons. |
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