| Synthesis and reactions of some 6-aryl and 2,6-diaryl-4-(4'-antipyrinyl)-2,3,4,5-tetrahydropyridasin-3-ones and screening for their antibacterial activities |
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| 作者姓名： | SAYED G. H. SHIBA S. A. RADWAN A. MOHAMED S. M. KHALIL M. |
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| 作者单位： | Chemistry Department Faculty of Science Ain Shams University Abbassia Cairo Egypt，Chemistry Department Faculty of Science Ain Shams University Abbassia Cairo Egypt，Al-Azhar University for Girls Abbassia Cairo Egypt，Al-Azhar University for Girls Abbassia Cairo Egypt，Al-Azhar University for Girls Abbassia Cairo Egypt |
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| 摘 要： | Some new pyridazinone derivatives(3) were synthesized through addition of antipyrin to β-aroylacrylic acids (1) followed by cyclization of the adducts. Reactions of 3 with ethyl bromoacetate,benzenesulfonyl chloride, benzoyl chloride and POCl_3 give N-substituted products and monochlorosub-stituted pyridazines (4), respectively. The reactions of the latter with thiourea give unexpected dithio-derivatives(5), which react with phenylhydrazine to give pyrazolopyridazino pyridazine derivatives (6).Reactions of 2 with NH_2OH in ethanol and pyridine afford oxime and oxazinone derivatives 7 and 8,tespectively. The antibacterial activities of several compounds were screened.
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