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Bistability of the system of nitrite utilization by Escherichia Coli: Analysis of a mathematical model
Authors:N A Ri  T M Khlebodarova  V V Kogai  S I Fadeev  V A Likhoshvai
Institution:14276. Institute of Cytology and Genetics, pr. Akad. Lavrent’eva 10, Novosibirsk, 630090, Russia
24276. Sobolev Institute of Mathematics, pr. Akad. Koptyuga 4, Novosibirsk, 630090, Russia
34276. Novosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russia
Abstract:Some mathematical model is analyzed describing nitrite utilization by E. coli cells grown in a flow chemostat. The system is of interest from the standpoint of the analysis of the mechanisms by which a cell utilizes toxic substrates in respiration. It is demonstrated that the system admits the appearance of two stationary nitrite concentrations; thus, it becomes bistable. The range of the nitrite supply rate into the chemostat for which the model is bistable is determined. The model predicts the possibility of a spontaneous death of the culture in transition between stationary states.
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