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A column-based ‘flush and flow’ system for the asymmetric α-chlorination of acid halides |
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| Institution: | 1. The Arnold and Mabel Beckman Laboratory for Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA;2. Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V. (IfOK), Buchbinderstraße 5-6, D-18055, Rostock, Germany |
| Abstract: | We describe a column based flow system in which a cinchona alkaloid based reagent/catalyst solid-phase promotes the asymmetric α-chlorination of acid chlorides to afford highly optically active α-chloroesters in high enantiomeric excess and in good yields. |
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