Oxidations catalyzed by phenylacetone monooxygenase from Thermobifida fusca |
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| Institution: | 1. Istituto di Chimica del Riconoscimento Molecolare, CNR, via Mario Bianco 9, 20131 Milano, Italy;2. Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands;1. Institute of Biology Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece;2. Biological Applications and Technologies Department, University of Ioannina, 45110 Ioannina, Greece;1. Department of Chemistry, Dibrugarh University, Dibrugarh 786004, Assam, India;2. Department of Chemical Sciences, Tezpur University, Napaam, Tezpur, Assam 784028, India;1. Institute of Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Athens, Greece;2. State University of Maringa, Department of Chemical Engineering, Maringa, Brazil;3. Biocatalysis & Organic Synthesis Group, Centre of Technology, Federal University of Rio de Janeiro, Rio de Janeiro, CEP22941909, Brazil;1. Department of Molecular Biotechnology and Kumho Life Science Laboratory, College of Agriculture and Life Sciences, Chonnam National University, Gwangju 61186, Republic of Korea |
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| Abstract: | Several organic sulfides, ketones and other organic systems have been tested as substrates in oxidation reactions catalyzed by the recently discovered phenylacetone monooxygenase from Thermobifida fusca. The biocatalytic properties of this Baeyer–Villiger monooxygenase have been studied, revealing reactivity with a large range of sulfides and ketones. Oxidations of several sulfoxides, an amine and an organoboron compound were also observed. The enzyme is able to oxidize a number of sulfides with excellent enantioselectivity, demonstrating the catalytic potential of this novel biocatalyst. |
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