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A simple catalytic route to naproxen
Institution:1. Organic Chemistry, Nankai University, Tianjin 300071, China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 300071, China;1. Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Kamýcká 129, 165 21 Prague 6, Czech Republic;2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo Sq. 2, 166 10 Prague 6, Czech Republic;3. University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic;4. Institute of Chemical Process Fundamentals, Academy of Sciences of the Czech Republic, Rozvojová 2/135, 165 02 Prague 6, Czech Republic;1. School of Life Sciences & State Laboratory of Bio-resources and Eco-environment, Ministry of Education, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610065, China;2. Medical and Nursing School, Chengdu University, Chengdu 610015, China;1. Ufa Institute of Chemistry – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS), Prospekt Oktyabrya 69, Ufa 450054, Russia;2. Institute Petrochemistry and Catalysis UFRC RAS, Ufa, Russia;3. A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia
Abstract:We report herein the asymmetric synthesis of naproxen involving catalytic enantioselective methylation for the first time. The reaction is conducted in a solid–liquid biphasic system using chiral quaternary ammonium salts.
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