Enantioselective microbial reduction of 6-oxo-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
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| Institution: | 1. Department of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen, Norway;2. Uni Research CIPR, Uni Research, P.O. Box 7810, 5020 Bergen, Norway;1. Department of Chemistry, University of Bergen, P.O. Box 7803, NO-5020 Bergen, Norway;2. Nofima BioLab, Kjerreidviken 16, NO-5141 Fyllingsdalen, Norway;1. Institute of Analytical Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria;2. Department of Organic Chemistry, Institute of Chemical Technology Prague, Technická 5, 16628 Prague, Czech Republic;1. Department of Hygiene, Sapporo Medical University, School of Medicine, Sapporo 060-8556, Japan;2. Department of Clinical Laboratory Medicine, Sapporo Medical University, Sapporo 060-8556, Japan;1. Post Graduate Program in Food Science and Technology, State University of Ponta Grossa (UEPG), Av. Carlos Cavalcanti 4748 Uvaranas Campus, CEP 84.030-900, Ponta Grossa, PR, Brazil;2. Post Graduate Program in Food Engineering, Federal University of Paraná (UFPR), Av. Cel. Francisco Heráclito dos Santos 210 Polytechnic Centre, 81531-980, Curitiba, PR, Brazil;3. Centre for Nuclear Energy in Agriculture, State University of São Paulo (USP), Av. Centenário, 303, Luiz de Queiroz Campus, 13900-470, Piracicaba, Brazil |
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| Abstract: | The enantioselective microbial reduction of 6-oxo-8-4-4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro4.5]decane-7,9-dione 1 to either of the corresponding (R)- or (S)-6-hydroxy-8-4-4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro4.5]decane-7,9-diones 2 and 3 is described. |
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