Kinetic resolution of 5-(hydroxymethyl)-3-phenyl-2-isoxazoline by using the ‘low-temperature method’ with porous ceramic-immobilized lipase |
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| Affiliation: | 1. Department of Entomology and Nematology, Comprehensive Cancer Center, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA;2. Department of Chemistry and General Chemical Technology, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, Volzhsky, Russia;3. Volgograd State Technical University, Volgograd, Russia;1. Department of Chemistry, Western Washington University, Bellingham, WA 98225, USA;2. Department of Chemistry and Biochemistry, University of San Diego, San Diego, CA 92110, USA |
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| Abstract: | A significant enhancement of the enantioselectivity (E value = 249) in the lipase-catalyzed resolution of a primary alcohol, racemic 5-(hydroxymethyl)-3-phenyl-2-isoxazoline (±)-1, was obtained by using the ‘low-temperature method’ (−60 °C) with porous ceramic-immobilized lipase (Amano PS-C II) and vinyl acetate in acetone. |
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