Construction of quaternary carbon stereocentres: catalytic enantioselective allylation assisted by a bimetallic catalytic system |
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| Affiliation: | 1. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA;2. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA |
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| Abstract: | The asymmetric allylic alkylation of prochiral aryl cyano esters has been carried out in the presence of a bi-component catalytic system containing a palladium and a rhodium complex modified by phosphorus containing chiral auxiliaries. The allyl derivatives were isolated in up to 63% ee. The chiral pocket ligands of Trost appear the most appropriate to produce the desired chiral derivatives. |
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