Chiral C2-symmetric ligands containing two binaphthyl units linked by 2,2′-bipyridyl bridge in asymmetric catalysis |
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| Institution: | 1. Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan;2. Laboratoire de Chimie Théorique, University of Namur, rue de Bruxelles, 61, B-5000 Namur, Belgium;1. Atlas Service Corps, Washington, DC 20001, USA;2. Department of Global Strategy and Programs, Susan G Komen, Dallas, TX 75244, USA;3. Howard University Hospital, Community and Family Medicine, Washington, DC 20001, USA |
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| Abstract: | The catalytic activities of new chiral C2-symmetric ligands 1–4 in the asymmetric alkylation of aromatic aldehydes with diethylzinc to give 1-arylpropanols are studied. In most cases, the yields were good and enantioselectivities up to 87% were observed. Copper-catalyzed cyclopropanation proceeded with ?51% enantioselectivity and ～3:1 trans/cis-diastereoselectivity. |
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