Synthesis of Glycosides of a Muramoyldipeptide with Chromone Aglycones

The synthesis of -(2-methyl-3-phenylchromonyl-7)- and -2-methyl-3-(3,4-trimethylenedioxy) phenylchromonyl-7]glycosides of the methyl ester of N-acetylmuramoyl-L-alanyl-D-isoglutamine, new derivatives of a muramoyldipeptide with chromone aglycones, is described. The starting arylglycosides of N-acetylglucosamine are prepared by glycosylation of 7-hydroxychromone derivatives with the peracetate of -glucosamine chloride catalyzed by a crown ether. The synthesized -aryl-4,6-O-isopropylidene-N-acetylmuramic acids are condensed with the dipeptide and deprotected to give the desired glycopeptides