The longitudinal changes of BOLD response and cerebral hemodynamics from acute to subacute stroke. A fMRI and TCD study |
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| Authors: | Claudia Altamura Matthias Reinhard Magnus-Sebastian Vry Christoph P Kaller Farsin Hamzei Fabrizio Vernieri Paolo Maria Rossini Andreas Hetzel Cornelius Weiller and Dorothee Saur |
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| Institution: | (1) Neurologia Clinica, Universit? Campus Bio-Medico di Roma, Italy;(2) Associazione Fatebenefratelli per la Ricerca (AFaR): Dipartimento di Neuroscienze, Fatebenefratelli, Isola Tiberina, Rome, Italy;(3) Department of Neurology, University Medical Center Freiburg, Germany;(4) Casa di Cura San Raffaele - Cassino, Cassino, Italy |
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| Abstract: | Background By mapping the dynamics of brain reorganization, functional magnetic resonance imaging MRI (fMRI) has allowed for significant
progress in understanding cerebral plasticity phenomena after a stroke. However, cerebro-vascular diseases can affect blood
oxygen level dependent (BOLD) signal. Cerebral autoregulation is a primary function of cerebral hemodynamics, which allows
to maintain a relatively constant blood flow despite changes in arterial blood pressure and perfusion pressure. Cerebral autoregulation
is reported to become less effective in the early phases post-stroke. |
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