Drug delivery from hydrophobic-modified mesoporous silicas: Control via modification level and site-selective modification |
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Authors: | Qunli Tang Yuxi Chen Jin Li Dong Wu |
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Institution: | a College of Materials Science and Engineering, and Center for High-Resolution Electron Microscopy, Hunan University, Changsha 410082, PR China b State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, PR China |
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Abstract: | Dimethylsilyl (DMS) modified mesoporous silicas were successfully prepared via co-condensation and post-grafting modification methods. The post-grafting modification was carried out by the reaction of the as-synthesized MCM-41 material (before CTAB removal) with diethoxydimethylsinale (DEDMS). N2 adsorption-desorption and 29Si MAS NMR characterization demonstrated that different amount of DMS groups were successfully incorporated into the co-condensation modified samples, and the functional DMS groups were placed selectively on the pore openings and external pore surfaces in the post-grafting modified samples. Subsequently, the controlled drug delivery properties from the resulting DMS-modified mesoporous silicas were investigated in detail. The drug adsorption experiments showed that the adsorption capacities were mainly depended on the content of silanol group (CSG) in the corresponding carriers. The in vitro tests exhibited that the incorporation of DMS groups greatly retarded the ibuprofen release rate. Moreover, the ibuprofen release profiles could be well modulated by varying DMS modification levels and site-selective distribution of functional groups in mesoporous carriers. |
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Keywords: | Drug delivery Ibuprofen Dimethylsilyl MCM-41 Hydrophobicity |
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