| 硅钨酸与氧氟沙星的相互作用 |
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| 引用本文： | 高盐生,周秋华,张红梅,王彦卿. 硅钨酸与氧氟沙星的相互作用[J]. 应用化学, 2010, 27(2): 178-182. DOI: 10.3724/SP.J.1095.2010.90098 |
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| 作者姓名： | 高盐生 周秋华 张红梅 王彦卿 |
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| 作者单位： | (1.江苏盐城技师学院 盐城；2.盐城师范学院化学化工学院 盐城 224002) |
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| 基金项目： | 江苏省高校自然科学基础研究项目，江苏省青蓝工程资助项目 |
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| 摘 要： | 利用荧光光谱及红外光谱法研究了硅钨杂多酸与氧氟沙星分子的相互作用。结果表明，在溶液中硅钨酸分子与氧氟沙星生成新的配合物，导致氧氟沙星溶液荧光的猝灭，其猝灭类型主要为静态猝灭。通过测定反应的表观结合常数、结合位点数及结合热力学参数，证明硅钨酸与氧氟沙星分子主要通过静电和疏水作用形成配合物, 配合物中的硅钨酸仍保持Keggin结构。
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| 关 键 词： | 硅钨酸 氧氟沙星 荧光光谱 相互作用 |
| 收稿时间： | 2009-02-16 |
| 修稿时间： | 2009-05-11 |
Interaction Between Silicotungstic Heteropolyacid and Ofloxacin |
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| GAO Yan-Sheng,ZHOU Qiu-Hua,ZHANG Hong-Mei,WANG Yan-Qing. Interaction Between Silicotungstic Heteropolyacid and Ofloxacin[J]. Chinese Journal of Applied Chemistry, 2010, 27(2): 178-182. DOI: 10.3724/SP.J.1095.2010.90098 |
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| Authors: | GAO Yan-Sheng ZHOU Qiu-Hua ZHANG Hong-Mei WANG Yan-Qing |
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| Affiliation: | (1.Yancheng Technician Institute,Yancheng;2.School of Chemistry and Chemical Engineering,Yancheng Teachers University,Yancheng 224002) |
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| Abstract: | A complex composed of ofloxacin(OFLX) and silicotungstic heteropolyacid(SiW) was studied by means of fluorescence and IR spectroscopies. SiW can quench the fluorescence of OFLX by forming a new complex. The binding site number n,apparent binding constant KA and corresponding thermodynamic parameters were measured at different temperatures. The result indicates that the electrostatic and hydrophobic interactions play a major role in stabilizing the complex. The IR spectrum confirms the presence of Keggin typ... |
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| Keywords: | silicotungstic heteropolyacid ofloxacin fluorescence spectroscopy interaction |
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