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Réactions SRN1 d'agents alkylants anthraquinoniques |
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| Authors: | Michel P. Crozet Patrice Vanelle Olivier Jentzer Santa Donini Jos Maldonado |
| Affiliation: | a Radicaux Libres et Synthèse, URA CNRS No 1412, Faculté des Sciences et Techniques de Saint-Jérôme, Université de Droit, d'Economie et des Sciences d'Aix-Marseille, BP 562, 13397 Marseille Cedex 20, France b Laboratoire de Chimie Organique, Faculté de Pharmacie, 27 Bd J. Moulin, 13385 Marseille Cedex 04, France |
| Abstract: | The C-alkylation reaction of three reductive alkylating agents prepared from 2-methylanthraquinone by 2-nitropropane anion is shown to proceed by the SRN1 mechanism. The SRN1 mechanism is confirmed by the leaving group effect and the inhibitory effects of dioxygen, p-dinitrobenzene, cupric chloride and di-tert-butylnitroxide. This reaction can be extended to 1-methyl-3-nitropyrrolidin-2-one anion. |
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