A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis |
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| Authors: | Maksim A Kolosov Valeriy D Orlov Dmitriy A Beloborodov Victor V Dotsenko |
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| Institution: | (1) Department of Organic Chemistry, V.N. Karazin Kharkov National University, 61077 Kharkov, Ukraine;(2) Physico-chemical Department, State Enterprise “Luganskstandart metrology”, 91021 Lugansk, Ukraine;(3) ChemEx Laboratory, Vladimir Dal’ East Ukrainian National University, 91034 Lugansk, Ukraine |
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| Abstract: | Despite prior reports of several really effective catalytic and non-catalytic approaches towards Biginelli’s 3,4-dihydropyrimidin-2(1H)-ones, an overwhelming number of new catalysts for the Biginelli reaction have been recently published. Most of the catalysts
are somewhat exotic, expensive, harmful and even uneffective in the absence of acidic additives. Herein we reduce the “yet-another-one-catalyst”
idea to absurdity by proposing NaCl promotes the reaction that actually requires no catalyst, neither rare nor expensive. |
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| Keywords: | Biginelli reaction Heterocycles Condensation Cyclization Sodium chloride |
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