Enantio- and diastereoselective allylmetalations: an easy and efficient access to the AB spiroketal of spongistatin |
| |
| Authors: | Allais Florent Cossy Janine |
| |
| Institution: | Laboratoire de Chimie Organique, Associé au CNRS, ESPCI, 10 rue Vauquelin, F-75231 Paris Cedex 05, France. |
| |
| Abstract: | reaction: see text] A unique combination of highly enantio- and diastereoselective allylmetalations and a one-pot "desacetalization/spiroketalization" have been employed to synthesize the AB spiroketal fragment (C1-C13) of spongistatin in 15 steps and in excellent diastereoselectivity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
