Natural triterpenoids as renewable nanos |
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Authors: | Braja Gopal Bag Chhabi Garai Rakhi Majumdar Michel Laguerre |
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Institution: | (1) Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore, 721 102, WB, India;(2) Institut Europ?en de Chimie et Biologie (IECB), CBMN, Universit? de Bordeaux-CNRS, UMR 5248, 2 rue Robert Escarpit, 33607 Pessac Cedex, France |
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Abstract: | Plant metabolites are the most significant source of renewable chemical feedstocks for a sustainable future. Among various
plant secondary metabolites, triterpenoids are a large and structurally diverse 30-carbons subset of the major component terpenoids.
Whereas the acyclic triterpene squalene can exist in many different conformations, the cyclic triterpenoids are more rigidified
and largely chiral. The tetra and pentacyclic triterpenoids are more abundant than other triterpenoids and molecules having
ten chiral centers are common. We show that acyclic and mono-cyclic to fused pentacyclic triterpenes are all nano-sized molecules
having varied rigid and flexible lengths. Monte-Carlo investigation of their conformational space revealed that the nanometric
lengths are maintained even in the folded conformers rendering all the triterpenoids useful as renewable
nanos. |
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Keywords: | |
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