Synthesis, Characterization and Antibacterial Activity of Schiff Base Derived from S-Methyldithiocarbazate and Methylisatin |
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| Authors: | Mohd Abdul Fatah Abdul Manan M Ibrahim M Tahir Karen A Crouse Fiona N-F How David J Watkin |
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| Institution: | (1) Faculty of Applied Sciences, Universiti Teknologi MARA, UiTM, 40450 Shah Alam, Selangor, Malaysia;(2) Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;(3) Chemical Chemistry Research Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QA, UK |
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| Abstract: | Abstract New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P − 1, Z = 2, V = 612.92(3) ?3 and unit cell parameters a = 6.8540(2) ?, b = 8.3022(2) ?, c = 11.5243(4) ?, α = 79.8186(13)°, β = 90.5224(14)° and γ = 72.1362(13)°. Crystal structure reveals that the compound exists
in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive
bacterial strains (Bacillus subtilis and Staphylococcus aureus) with the inhibition zones of 16 and 12 mm, respectively. |
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