Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes |
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| Authors: | Young Paul C Hadfield Maximillian S Arrowsmith Lynn Macleod Kristina M Mudd Richard J Jordan-Hore James A Lee Ai-Lan |
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| Institution: | School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, Scotland, United Kingdom. |
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| Abstract: | Depending on the conditions employed, gold(I)-catalyzed addition of indoles to 3,3-disubstituted cyclopropenes can be controlled to yield either 3-(E)-vinylindoles (3) or bis-indolylalkanes (4). If the cyclopropene substituents are sterically bulky, unprecedented gold-catalyzed oxidation under air occurs to yield bis-indolylalkene (5) and epoxide (6) at room temperature. |
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