Electron transfer reduction of carboxylic acids using SmI2-H2O-Et3N |
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Authors: | Szostak Michal Spain Malcolm Procter David J |
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Affiliation: | School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom. |
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Abstract: | The first general method for efficient electron transfer reduction of carboxylic acids has been developed. The protocol using SmI(2)-H(2)O-Et(3)N allows for reduction of a variety of carboxylic acids in excellent yields and provides an attractive alternative to processes mediated by reactive alkali metals, lithium aluminum hydride, and boron hydrides. Of broader significance, the method allows acyl radical equivalents to be generated from carboxylic acids under mild reaction conditions. |
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