Elastic properties of a protein-polymer-grafted surface |
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Authors: | Keller Kristen Amirian Armen Akcora Pinar |
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Institution: | Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, New Jersey 07030, USA. |
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Abstract: | Surfaces grafted with poly(methyl methacrylate) (PMMA) and streptavidin were synthesized through click chemistry to investigate the role of surface stiffness on protein adsorption as the hydrophilic and hydrophobic surface coverage of the substituents vary. Surface topographies coupled with the nanoindentation results indicated that, with the appropriate selections of polymer coverage and chain length, the extent of non-specific protein adhesion could be controlled by the hydrophobic interactions between PMMA, biotin, and streptavidin. It was shown that, when the molecular weight and stiffness of PMMA was close to that of streptavidin, patchy PMMA morphologies were obtained, which help inhibit the non-specific adsorption of streptavidin. |
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