| A Novel Preparation Method of C-Terminal Glutamine Dipeptides |
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| 作者姓名： | QIANShao-Song LIUYi CHENRan LIJia-You WUXiao-Yan JIAOQing-Cai |
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| 作者单位： | QIAN Shao-Song，LIU Yi，CHEN Ran，LI Jia-You，WU Xiao-Yan，JIAO Qing-Cai College of Life Science，Nanjing University，Nanjing 210093 |
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| 基金项目： | Supported by State Innovation Fund(02CJ-13-01-16) |
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| 摘 要： | A novel synthesis method of dipeptides containing glutamine is reported. Protected L-amino acids were prepared by using inexpensive phthaloyl as the protecting group. Then the phthaloyl-L-amino acids were condensed with glutamine salts by the mixed anhydride method to afford phthaloyl dipeptides. Subsequently, the phthaloyl was removed from the dipeptides with hydrazine hydrate. As a result, optically pure glutamine-containing dipeptides were obtained in good yields.
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| 关 键 词： | 制备方法 C-谷氨酸二肽 L-丙氨酰基-L-谷氨酸盐 甘氨酰基-L-谷氨酸盐 混合酐 |
| 文章编号： | 1000-0518(2006)01-0109-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2005年4月15日 |
A Novel Preparation Method of C-Terminal Glutamine Dipeptides |
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| QIANShao-Song,LIUYi,CHENRan,LIJia-You,WUXiao-Yan,JIAOQing-Cai.A Novel Preparation Method of C-Terminal Glutamine Dipeptides[J].Chinese Journal of Applied Chemistry,2006,23(1):109-0. |
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| Authors: | QIAN Shao-Song LIU Yi CHEN Ran LI Jia-You WU Xiao-Yan JIAO Qing-Cai |
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| Institution: | College of Life Science,Nanjing University,Nanjing 210093 |
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| Abstract: | A novel synthesis method of dipeptides containing glutamine is reported. Protected L-amino acids were prepared by using inexpensive phthaloyl as the protecting group. Then the phthaloyl-L-amino acids were condensed with glutamine salts by the mixed anhydride method to afford phthaloyl dipeptides. Subsequently, the phthaloyl was removed from the dipeptides with hydrazine hydrate. As a result, optically pure glutamine-containing dipeptides were obtained in good yields. |
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| Keywords: | N-phthaloyl amino acids L-alanyl-L-glutamine Glycyl-L-glutamine mixed anhydride |
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