Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc |
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| Authors: | Alexakis Alexandre Polet Damien Rosset Stéphane March Sébastien |
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| Affiliation: | Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, Genève 4, Switzerland CH-1211. alexandre.alexakis@chiorg.unige.ch |
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| Abstract: | Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins. |
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