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Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis
引用本文:Shao Ping FU,Xiao Zhe ZHANG,Feng ZHANG,Qing XU,Hong Bin XIAO,Xin Miao LIANG Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023. Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis[J]. 中国化学快报, 2005, 16(9): 1233-1236
作者姓名:Shao Ping FU  Xiao Zhe ZHANG  Feng ZHANG  Qing XU  Hong Bin XIAO  Xin Miao LIANG Dalian Institute of Chemical Physics  Chinese Academy of Sciences  Dalian 116023
作者单位:Shao Ping FU,Xiao Zhe ZHANG,Feng ZHANG,Qing XU,Hong Bin XIAO,Xin Miao LIANG Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023
基金项目:The authors are grateful to the National Natural Science Foundation of China (Grant No. 20235020 and 20372062) for financial support. We also thank Dr. Long Xin Wang for many stimulating discussions.
摘    要:Most drugs are usually bound to proteins such as serum albumin,α1-acid glycoprotein,lipoprotein,and other blood constituents.The plasma concentration of an unbound drug shows better correlation to the pharmaceutical activity1.It is therefore necessary to know the extent of drug-protein binding in order to adjust the optimal therapeutic dose of the drug.Strychnos nux-vomica L.(Loganiaceae)is an evergreen tree native to southeast Asia.Its dried seeds are used for treatment of nervous diseases…

关 键 词:番木鳖碱 白蛋白 血清 毛细管 电泳分析
收稿时间:2004-11-15

Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis
Shao Ping FU,Xiao Zhe ZHANG,Feng ZHANG,Qing XU,Hong Bin XIAO,Xin Miao LIANG Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian. Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis[J]. Chinese Chemical Letters, 2005, 16(9): 1233-1236
Authors:Shao Ping FU  Xiao Zhe ZHANG  Feng ZHANG  Qing XU  Hong Bin XIAO  Xin Miao LIANG Dalian Institute of Chemical Physics  Chinese Academy of Sciences  Dalian
Affiliation:Shao Ping FU,Xiao Zhe ZHANG,Feng ZHANG,Qing XU,Hong Bin XIAO,Xin Miao LIANG Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023
Abstract:
Keywords:Strychnine   binding constant   capillary electrophoretic frontal analysis   bovine serumalbumin
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