质谱在高通量快速检测技术中的应用研究进展

质谱是现代分析测试技术中同时具备了灵敏度高、特异性好、分析速度快等特性的普适性方法,现已被广泛应用于食品检验、环境监测、药物筛选、临床医学等众多领域的高通量快速检测技术中。该文针对近年来低分辨质谱、高分辨质谱以及原位电离质谱技术在高通量快速检测,特别是小分子化合物的高通量快速检测中的应用研究进展进行了综述,并对质谱技术用于高通量快速检测的发展趋势及应用前景进行了展望,以期为相关领域的科技人员提供理论支持和技术参考。

Advances in Application of Mass Spectrometry in High-throughput and Rapid Detection

Mass spectrometry is accepted as a universal tool with high sensitivity,specificity and speed among various modern analytical technologies,and has been widely applied as a high-throughput and rapid detection technology in fields of food inspection,environmental monitoring,drug screening,clinical medicine,etc.In this paper,recent advances in low-resolution mass spectrometry(LRMS),high-resolution mass spectrometry(HRMS) and ambient ionization mass spectrometry(AIMS) in high-throughput and rapid detection,particularly toward small molecule compounds have been reviewed,and the trends and prospective for the development of mass spectrometry have been discussed,which may provide a theoretical support and a technical guidance for the researchers engaged in relevant fields.