Voltammetric behavior and quantitative determination of ambazone concentrations in urine and in a pharmaceutical formulation |
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Authors: | Sylwia Smarzewska Dariusz Guziejewski Monika Skowron Slawomira Skrzypek Witold Ciesielski |
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Institution: | 1. Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, 91-403, Lodz, Poland
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Abstract: | The use of square wave adsorptive stripping voltammetry (SWAdSV) in conjunction with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) for the analytical determination of ambazone in urine samples and pharmaceutical formulations is described. A single reduction peak in Britton-Robinson buffer at pH 4.0 was detected at about ?1.4 V versus Ag/AgCl. Mechanistic studies have shown that the compound can act as an electrocatalyst. The method was validated. The analytical curve was linear in the concentration range from 1.0×10?9 to 1.0×10?7 mol L?1. The detection and quantification limits were found to be 3.0×10?10 mol L?1 and 1.0×10?9 mol L?1, respectively. The proposed method was successfully applied to ambazone determination in real samples. |
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