Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics |
| |
Authors: | Biron Eric Chatterjee Jayanta Kessler Horst |
| |
Affiliation: | Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universit?t München, Garching, Germany. |
| |
Abstract: | [reaction: see text] We report highly efficient two-step procedures for the synthesis of 1,3-oxazole-, thiazole-, and imidazole-containing peptides on solid phase from dipeptides composed of C-terminal threonine, serine, cysteine, or diaminopropionic acid by using different cyclodehydration procedures followed or preceded by oxidation. The methods are compatible with Fmoc solid-phase peptide synthesis conditions and with N-Fmoc, N-Boc, N-Cbz, and N-Alloc protecting groups. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|